Prebiotic treatment for the modulation of post-stroke neuroinflammation
Institut für Schlaganfall- und Demenzforschung, Schlaganfall-Immunologie
Acute brain injuries are traditionally not regarded as classical neuroinflammatory disorders, yet, they trigger a plethora of immune responses well comparable to those occurring in other primary inflammatory brain diseases. Key components of neuroinflammation after stroke and TBI are the activation of resident immune cells as well as the invasion of circulating leukocytes into the brain. We have recently identified the gut microbiome as a key modulator of the post-stroke neuroinflammatory response. Moreover, the gut microbiota are producers of several immunoactive metabolites which have a profound impact on recovery from acute brain injuries. Acute brain lesions induce dysbiosis of the microbiome; in turn, changes in the gut microbiota affect neuroinflammatory and functional outcome after brain injury. Therefore, the goal of this project will be to test the impact of prebiotic treatment to shape a pro-regenerative micrbiota composition. We will test the impact of the prebiotic treatment on microbiota composition (next-generation sequencing), blood metabolomics (mass spectrometry), the neuroinflammaory response (flow cytometry and genetics) and stroke outcome (behavior and histology).
Findings from this study will guide further translational development of microbiota-targeted therapies for the treatment of stroke patients. This project will encompass a broad panel of cutting-edge methodology using stroke models, advanced immunology tools and –omics approaches to study the therapeutic impact on metabolomic profiles and microbiological changes.
The doctoral candidate will work under the direct supervision of the laboratory head, Dr. Liesz, and will be supported by an experienced postdoctoral scientist in learning the experimental techniques. All methods are already established in the laboratory and will be taught tot he candidate on site.
The ideal candidate should be a medical student who is ready to invest 2 complete semesters in the project for a high quality thesis. The position will be in an international, dynamic and “open-door” atmosphere, with access to state-of-the-art laboratory facilities and technologies. The duration is 1 year with the possibility of extension if desired. Successful candidates will receive a student assistant contract (Studentische Hilfskräftevertrag).
Geschätzte Dauer: 12 Monate
Successful candidates will receive student assistant contract (Studentische Hilfskräftevertrag). Access to ISD/CSD infrastructure and weekly seminars.