Role of microtubule stabilization in promoting axonal plasticity and functional recovery following spinal cord injury
Institut für Klinische Neuroimmunologie, Spinal cord repair
Our laboratory at the Institute of Clinical Neuroimmunology of the Ludwig Maximilians
University in Munich ( http://ini.klinikum.uni-muenchen.de/bareyre_lab ) is interested in axonal plasticity following CNS injuries. In projects funded as part of the newly established excellence cluster “Munich Cluster for Systems Neurology” (www.synergy-munich.de) and the collaborative research centers “Assembly and function of neuronal circuits” and “checkpoints of CNS recovery” we want to study how axonal connections remodel following spinal cord injury when the neuronal cytoskeleton is stabilized. To do so we focus on microtubule stabilization using two approaches with a drug systemically delivered into spinal cord animals or working with knockout mice. We will use modern behavioral and in situ microscopy techniques in combination with genetic and viral tracing techniques to reveal axonal adaptive changes. We offer an international and dynamic atmosphere with access to state of the art laboratory facilities in the new Biomedical Building (BMC). We are looking for a highly motivated student with keen interest in neuroscience and excellent communication skills in English.
Geschätzte Dauer: 12 Monate
If there is a corresponding interest, a financial support is possible through employment as a student assistant.